The development of resistance against antibiotics constitutes a real problem in public health and encourages the search for new strategies to fight bacterial infections. Moreover, climate change leads to the appearance in the ocean of pathogenic bacteria (for example Vibrio) which not only impact human health but are also involved in coral bleaching. A better knowledge of cnidarian/bacteria relationships will allow better understanding of certain coral pathologies and will therefore have consequences in the field of environmental management. In turn, corals are a host-pathogen research model that remains to be developed to uncover conserved antimicrobial strategies in humans.
The main goal of this project is to establish a reproducible model of infection of the anemone Aiptasia pallida in order to identify and study the importance of "Nod-like receptors" NLRs during infection by Vibrio. parahaemolyticus. They determine the transcriptional regulations of the NLRs of Aiptasia and more broadly, they seek to define the genes modulated by V. parahaemolyticus. Bioinformatics cross-analysis should allow them to define a profile of conserved genes expressed in response to infection. Particular attention will be paid to the regulation of NLRs. Genes conserved in humans will then be studied in a macrophage infection system. They will use classical RNA interference approaches followed by the measurement of cytokines produced as well as the determination of pathogen elimination or persistence in these macrophages. Thus, they should identify new actors of innate immunity and signaling pathways involved in host defense against infection.
The EnvironGeneMed project is led by the Mediterranean Center of Molecular Medicine (C3M) of the University Côte d'Azur (UCA), and the Scientific Center of Monaco (CSM).
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