Publications conjointes

  • Cormerais, Y., Vučetić, M., Parks, S. K., & Pouyssegur, J. (2021). Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer. International Journal of Molecular Sciences22(1), 23.
  • Dufies, O., Doye, A., Courjon, J., Torre, C., Michel, G., Loubatier, C., et al (2021). Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice. Nature Microbiology, 6(3), 401-412.
  • Dufies, M., Verbiest, A., Cooley, L. S., Ndiaye, P. D., He, X., Nottet, N., Souleyreau, W., Hagege, A., Torrino, S., Parola, J., Giuliano, S., Borchiellini, D., Schiappa, R., Mograbi, B., Zucman-Rossi, J., Bensalah, K., Ravaud, A., Auberger, P., Bikfalvi, A., Chamorey, E., et al. (2021). Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma. Communications biology4(1), 166.
  • Dumond, A., Brachet, E., Durivault, J. et al. (2021). Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma. J Exp Clin Cancer Res 40, 33.
  • Otte, S., Ipiña, E. P., Pontier-Bres, R., Czerucka, D., & Peruani, F. (2021). Statistics of pathogenic bacteria in the search of host cells. Nature Communications, 12(1), 1-9.
  • Cassim, S., Vučetić, M., Ždralević, M., & Pouyssegur, J. (2020). Warburg and beyond: the power of mitochondrial metabolism to collaborate or replace fermentative glycolysis in cancer. Cancers, 12(5), 1119.
  • Daher, B., Vučetić, M., & Pouysségur, J. (2020). Cysteine depletion, a key action to challenge cancer cells to ferroptotic cell death. Frontiers in Oncology, 10, 723.
  • Dumond, A., Demange, L., & Pagès, G. (2020). Les neuropilines-Des cibles pertinentes pour améliorer le traitement des cancers. médecine/sciences36(5), 487-496.
  • Dumond, A. & Pagès, G., (2020). Neuropilins, as relevant oncology target: Their role in the tumoral microenvironment. Frontiers in Cell and Developmental Biology8, 662.
  • Grépin, R., Guyot, M., Dumond, A., Durivault, J., Ambrosetti, D., Roussel, J. F., Dupré, F., Quintens, H., & Pagès, G. (2020). The combination of bevacizumab/Avastin and erlotinib/Tarceva is relevant for the treatment of metastatic renal cell carcinoma: the role of a synonymous mutation of the EGFR receptor. Theranostics10(3), 1107–1121.
  • Grytsai, O., Valiashko, O., Penco-Campillo, M., Dufies, M., Hagege, A., Demange, L., et al. (2020). Synthesis and biological evaluation of 3-amino-1, 2, 4-triazole derivatives as potential anticancer compounds. Bioorganic Chemistry104, 104271.
  • Fabbri, L., Dufies, M., Lacas-Gervais, S., Gardie, B., Gad-Lapiteau, S., Parola, J., et al (2020). Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients. Theranostics, 10(6), 2696.
  • Flores, J. M., Bourdin, G., Altaratz, O., Trainic, M., Lang-Yona, N., Dzimban, E., Steinau, S., Tettich, F., Planes, S., Allemand, D., et al. (2020). Tara Pacific Expedition’s Atmospheric Measurements of Marine Aerosols across the Atlantic and Pacific Oceans: Overview and Preliminary Results. Bulletin of the American Meteorological Society, 101(5), E536-E554.
  • Mazzio, E., Badisa, R., Mack, N., Cassim, S., Zdralevic, M., Pouyssegur, J., & Soliman, K. (2020). Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase. Cancer genomics & proteomics, 17(5), 469–497.
  • Meyenberg Cunha-de Padua, M., Fabbri, L., Dufies, M., Lacas-Gervais, S., Contenti, J., Voyton, C., Fazio, S., Irondelle, M., Mograbi, B., Rouleau, M., Sadaghianloo, N., Rovini, A., Brenner, C., Craigen, W. J., Bourgeais, J., Herault, O., Bost, F., & Mazure, N. M. (2020). Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC. Cancers12(11), 3484.
  • Montemagno, C., Cassim, S., Pouyssegur, J., & Broisat, A. (2020). From malignant progression to therapeutic targeting: current insights of mesothelin in pancreatic ductal adenocarcinoma. International Journal of Molecular Sciences, 21(11), 4067.
  • Montemagno, C., Hagege, A., Borchiellini, D., Thamphya, B., Rastoin, O., Ambrosetti, D., Dufies, M., et al (2020). Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma. Oncoimmunology, 9(1), 1846901.
  • Montemagno, C.; Pagès, G. (2020). Metastatic Heterogeneity of Breast Cancer: Companion and Theranostic Approach in Nuclear Medicine. Cancers12, 821.
  • Montemagno, C., & Pagès, G. (2020). Resistance to anti-angiogenic therapies: a mechanism depending on the time of exposure to the drugs. Frontiers in Cell and Developmental Biology8.
  • Montemagno, C., & Pagès, G. (2020). Targeting Mesothelin in Pancreatic Ductal Adeno-Carcinoma PDAC. Journal of Cellular Immunology2(2).
  • Ottaviani, A., Eid, R., Zoccola, D., Pousse, M., Dubal, J. M., Barajas, E., Jamet K., Lebrigand K., Lapébie P., Baudoin C., et al (2020). Longevity strategies in response to light in the reef coral Stylophora pistillata. Scientific reports, 10(1), 1-10.
  • Parks, S. K., Mueller-Klieser, W., & Pouysségur, J. (2020). Lactate and acidity in the cancer microenvironment. Annual Review of Cancer Biology, 4, 141-158.
  • Penco-Campillo, M., Comoglio, Y., Morel, Á. J. F., Hanna, R., Durivault, J., Leloire, M., et al. (2020). VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells. Communications biology3(1), 1-14.
  • Rastoin, O., & Dufies, M. (2020). Experimental Models in Neovascular Age Related Macular Degeneration. International Journal of Molecular Sciences21(13), 4627.
  • Sadaghianloo, N., Contenti, J., Dufies, M., Parola, J., Rouleau, M., Lee, S., Peyron, J. F., Fabbri, L., Hassen-Khodja, R., Pouysségur, J., Bost, F., Jean-Baptiste, E., Dardik, A., & Mazure, N. M. (2020). Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia. Journal of cellular and molecular medicine, 24(5), 2931–2941.
  • Savary, C., Kim, A., Lespagnol, A. et al. (2020). Depicting the genetic architecture of pediatric cancers through an integrative gene network approach. Sci Rep 10, 1224.
  • Seneca, F., Davtian, D., Boyer, L., & Czerucka, D. (2020). Gene expression kinetics of Exaiptasia pallida innate immune response to Vibrio parahaemolyticus infection. BMC genomics, 21(1), 1-16.
  • Sun, X., Berger, R. S., Heinrich, P., Marchiq, I., Pouyssegur, J., Renner, K., ... & Dettmer, K. (2020). Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS. Metabolites, 10(7), 292.
  • Vucetic, M., Daher, B., Cassim, S., Meira, W., & Pouyssegur, J. (2020). Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis. Cell Death & Disease, 11(9), 1-13.
  • Brachet, E., Dumond, A., Liu, W. Q., Fabre, M., Selkti, M., Raynaud, F., ... & Demange, L. (2019). Synthesis, 3D-structure and stability analyses of NRPa-308, a new promising anti-cancer agent. Bioorganic & medicinal chemistry letters29(24), 126710.
  • Cassim, S., & Pouyssegur, J. (2019). Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response. International journal of molecular sciences, 21(1), 157.
  • Cormerais, Y., Pagnuzzi-Boncompagni, M., Schrötter, S., Giuliano, S., Tambutté, E., Endou, H., Wempe, M. F., Pagès, G., Pouysségur, J., & Picco, V. (2019). Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma. Journal of cellular and molecular medicine, 23(4), 2711–2718.
  • Cormerais, Y., Vucetic, M., & Pouysségur, J. (2019). Targeting amino acids transporters (SLCs) to starve cancer cells to death. Biochemical and biophysical research communications, 520(4), 691–693.
  • Daher, B., Parks, S. K., Durivault, J., Cormerais, Y., Baidarjad, H., Tambutte, E., Pouysségur, J., & Vučetić, M. (2019). Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses. Cancer research, 79(15), 3877–3890.
  • Dufies, M., Grytsai, O., Ronco, C., Camara, O., Ambrosetti, D., Hagege, A., Parola, J., Mateo, L., Ayrault, M., Giuliano, S., Grépin, R., Lagarde, N., Montes, M., Auberger, P., Demange, L., Benhida, R., & Pagès, G. (2019). New CXCR1/CXCR2 inhibitors represent an effective treatment for kidney or head and neck cancers sensitive or refractory to reference treatments. Theranostics9(18), 5332–5346.
  • Flores, J. M., Bourdin, G., Altaratz, O., Trainic, M., Lang-Yona, N., Dzimban, E., et al (2020). Tara Pacific Expedition’s Atmospheric Measurements of Marine Aerosols across the Atlantic and Pacific Oceans: Overview and Preliminary Results. Bulletin of the American Meteorological Society, 101(5), E536-E554.
  • Giuliano, S., Dufies, M., Ndiaye, P. D., Viotti, J., Borchiellini, D., Parola, J., Pagès, G., et al (2019). Resistance to lysosomotropic drugs used to treat kidney and breast cancers involves autophagy and inflammation and converges in inducing CXCL5. Theranostics, 9(4), 1181.
  • Gorsky, G., Bourdin, G., Lombard, F., Pedrotti, M. L., Audrain, S., Bin, N., Chabot, G., et al (2019). Expanding Tara Oceans protocols for underway, ecosystemic sampling of the ocean-atmosphere interface during Tara Pacific expedition (2016-18). Frontiers in Marine Science, 6, 750.
  • Guerrini, G., Durivault, J., Filippi, I., Criscuoli, M., Monaci, S., Pouyssegur, J., et al (2019). Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells. Biochemical and biophysical research communications, 516(2), 408-413.
  • Ibáñez L., Pontier-Bres R., Larbret F., Rekima A., Verhasselt V., Blin-Wakkach C. and Czerucka D. (2019). Saccharomyces boulardii strain CNCM I-745 modify mononuclear phagocyte homeostasis in the small intestine of mice following Salmonella Typhimurium infection. Frontier in Immunology; 10: 643.
  • Kaminski, L., Torrino, S., Dufies, M., Djabari, Z., Haider, R., Roustan, F. R., ... & Bost, F. (2019). PGC1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness. Cancer research79(13), 3268-3280.
  • Meyenberg Cunha-de Padua, M., Noleto, G. R., de Oliveira Petkowicz, C. L., Cadena, S., Bost, F., Pouysségur, J., & Mazure, N. M. (2019). Hypoxia protects against the cell death triggered by oxovanadium-galactomannan complexes in HepG2 cells. Cellular & molecular biology letters, 24, 18.
  • Montemagno, C., Cassim, S., Trichanh, D., Savary, C., Pouyssegur, J., Fagret, D., et al (2019). 99mTc-A1 as a novel imaging agent targeting mesothelin-expressing pancreatic ductal adenocarcinoma. Cancers, 11(10), 1531.
  • Montemagno, C., Dumas, L., Cavaillès, P., Ahmadi, M., Bacot, S., Debiossat, M., Soubies, A., Djaïleb, L., Leenhardt, J., Leiris, N., Dufies, M., Pagès, G., Hernot, S., Devoogdt, N., Perret, P., Riou, L., Fagret, D., Ghezzi, C., & Broisat, A. (2019). In Vivo Assessment of VCAM-1 Expression by SPECT/CT Imaging in Mice Models of Human Triple Negative Breast Cancer. Cancers11(7), 1039.
  • Ndiaye, P. D., Dufies, M., Giuliano, S., Douguet, L., Grépin, R., Durivault, J., ... & Pagès, G. (2019). VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness. Theranostics9(3), 661.
  • Ndiaye, P. D., & Pagès, G. (2019). VEGF-C et vaisseaux lymphatiques-Une épée à double tranchant dans le développement tumoral et la dissémination métastatique. médecine/sciences35(2), 132-137.
  • Perez Ipina, E., Otte, S., Pontier-Bres, R., Czerucka, D., Peruani, F., (2019). Bacteria display optimal transport near surfaces. Nature Physics. 15, 610-615.
  • Planes, S., Allemand, D., Agostini, S., Banaigs, B., Boissin, E., Boss, E., et al (2019). The Tara Pacific expedition—A pan-ecosystemic approach of the “-omics” complexity of coral reef holobionts across the Pacific Ocean. PLoS biology, 17(9), e3000483.
  • Pouysségur J. (2019). The great joy of a BBRC editor. Biochemical and biophysical research communications, 520(4), 694.
  • Pouysségur, J., & Ždralević, M. (2019). Reply to Beltinger: Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism. Journal of Biological Chemistry, 294(1), 67-67.
  • Renner, K., Bruss, C., Schnell, A., Koehl, G., Becker, H. M., Fante, M., et al (2019). Restricting glycolysis preserves T cell effector functions and augments checkpoint therapy. Cell reports, 29(1), 135-150.
  • Allemand, D., and Furla, P. (2018). How does an animal behave like a plant? Physiological and molecular adaptations of zooxanthellae and their hosts to symbiosis. Comptes rendus biologies 341 : 276-280.
  • Ambrosetti, D., Dufies, M., Dadone, B., Durand, M., Borchiellini, D., Amiel, J., Pouyssegur, J., Rioux-Leclercq, N., Pages, G., Burel-Vandenbos, F., & Mazure, N. M. (2018). The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PloS one13(2), e0193477.
  • Bohn, T., Rapp, S., Luther, N. et al. (2018). Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages. Nat Immunol 19, 1319–1329.
  • Brolih, S., Parks, S. K., Vial, V., Durivault, J., Mostosi, L., Pouysségur, J., Pagès, G., & Picco, V. (2018). AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity. BMC cancer18(1), 249.
  • Cormerais, Y., Massard, P. A., Vucetic, M., Giuliano, S., Tambutté, E., Durivault, J., Vial, V., Endou, H., Wempe, M. F., Parks, S. K., & Pouyssegur, J. (2018). The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). The Journal of biological chemistry293(8), 2877–2887.
  • Dufies, M., Nollet, M., Ambrosetti, D., Traboulsi, W., Viotti, J., Borchiellini, D., Grépin, R., Parola, J., Giuliano, S., et al. (2018). Soluble CD146 is a predictive marker of pejorative evolution and of sunitinib efficacy in clear cell renal cell carcinoma. Theranostics8(9), 2447–2458.
  • Liu, W. Q., Lepelletier, Y., Montès, M., Borriello, L., Jarray, R., Grépin, R., et al. (2018). NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft model. Cancer letters414, 88-98.
  • Pagès G. (2018). The path to « the Golden Age » for the treatment of metastatic renal cell carcinoma. Oncotarget9(60), 31564–31565.
  • Persaud, A., Cormerais, Y., Pouyssegur, J., & Rotin, D. (2018). Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin. Journal of cell science131(1), jcs211755.
  • Polena, H., Creuzet, J., Dufies, M., Sidibé, A., Khalil-Mgharbel, A., Salomon, A., Deroux, A., Quesada, J. L., Roelants, C., Filhol, O., Cochet, C., Blanc, E., Ferlay-Segura, C., Borchiellini, D., Ferrero, J. M., Escudier, B., Négrier, S., Pages, G., & Vilgrain, I. (2018). The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma. British journal of cancer118(9), 1179–1188.
  • Provost, J., Garofalakis, A., Sourdon, J. et al. (2018) Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging. Nat Biomed Eng 285–94.
  • Ždralević, M., Brand, A., Di Ianni, L., Dettmer, K., Reinders, J., Singer, K., et al. (2018). Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism. Journal of Biological Chemistry293(41), 15947-15961.
  • Ždralević, M., Vučetić, M., Daher, B., Marchiq, I., Parks, S. K., & Pouysségur, J. (2018). Disrupting the ‘Warburg effect’re-routes cancer cells to OXPHOS offering a vulnerability point via ‘ferroptosis’-induced cell death. Advances in biological regulation68, 55-63.
  • Courtial, L., Picco, V., Grover, R. et al. (2017). The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells. Sci Rep 7, 45713.
  • Courtial, L., Picco, V., Pagès, G., & Ferrier-Pagès, C. (2017). Validation of commercial ERK antibodies against the ERK orthologue of the scleractinian coral Stylophora pistillata. F1000Research6.
  • Cunha de Padua, M. , Delodi, G., Vučetić, M., Durivault, J., Vial, V., Bayer, P., et al. (2017). Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia. Oncotarget8(50), 87623.
  • Dufies, M., Giuliano, S., Ambrosetti, D., Claren, A., Ndiaye, P. D., Mastri, M., Moghrabi, W., Cooley, L. S., et al. (2017). Sunitinib Stimulates Expression of VEGFC by Tumor Cells and Promotes Lymphangiogenesis in Clear Cell Renal Cell Carcinomas. Cancer research77(5), 1212–1226.
  • Dufies, M., Giuliano, S., Viotti, J., Borchiellini, D., Cooley, L. S., Ambrosetti, D., et al. (2017). CXCL7 is a predictive marker of sunitinib efficacy in clear cell renal cell carcinomas. British journal of cancer117(7), 947–953.
  • Guyot, M., Hilmi, C., Ambrosetti, D., Merlano, M., Nigro, C. L., Durivault, J., et al. (2017). Targeting the pro-angiogenic forms of VEGF or inhibiting their expression as anti-cancer strategies. Oncotarget8(6), 9174.
  • Leduc, M., Richard, J., Costes, S. et al. (2017) ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB. Diabetologia 601999–2010.
  • Noor, S. I., Pouyssegur, J., Deitmer, J. W., & Becker, H. M. (2017). Integration of a 'proton antenna' facilitates transport activity of the monocarboxylate transporter MCT4. The FEBS journal284(1), 149–162.
  • Parks, S. K., Cormerais, Y., Durivault, J., & Pouyssegur, J. (2017). Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells. Oncotarget8(6), 10225–10237.
  • Parks, S. K., Cormerais, Y., & Pouysségur, J. (2017). Hypoxia and cellular metabolism in tumour pathophysiology. The Journal of physiology595(8), 2439-2450.
  • Parks, S. K., & Pouysségur, J. (2017). Targeting pH regulating proteins for cancer therapy–Progress and limitations. In Seminars in cancer biology (Vol. 43, pp. 66-73). Academic Press.
  • Shiokawa, M., Lu, X., Miyake, Y., Ishikawa, E., Pagès, G., Pouysségur, J., ... & Yamasaki, S. (2017). Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice. International immunology29(10), 479-485.
  • Tsuji, T., Kurokawa, Y., Chiche, J., Pouysségur, J., Sato, H., Fukuzawa, H., ... & Kambe, T. (2017). Dissecting the process of activation of cancer-promoting zinc-requiring ectoenzymes by zinc metalation mediated by ZNT transporters. Journal of Biological Chemistry292(6), 2159-2173.
  • Vučetić, M., Cormerais, Y., Parks, S. K., & Pouysségur, J. (2017). The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code. Frontiers in oncology7, 319.
  • Wehenkel, M., Corr, M., Guy, C. S., Edwards, B. A., Castellaw, A. H., Calabrese, C., et al. (2017). Extracellular signal-regulated kinase signaling in CD4-expressing cells inhibits osteochondromas. Frontiers in immunology8, 482.
  • Ždralević, M., Marchiq, I., de Padua, M. M. C., Parks, S. K., & Pouysségur, J. (2017). Metabolic plasiticy in cancers—distinct role of glycolytic enzymes GPI, LDHs or membrane transporters MCTs. Frontiers in oncology7, 313.
  • Zoccola, D., Morain, J., Pagès, G., Caminiti-Segonds, N., Giuliano, S., Tambutté, S., and Allemand, D. (2017). Structural and functional analysis of coral Hypoxia Inducible Factor. PloS one 12, e0186262.
  • Benhamou, Y., Picco, V., & Pages, G. (2016). The telomere proteins in tumorigenesis and clinical outcomes of oral squamous cell carcinoma. Oral oncology57, 46-53.
  • Benhamou, Y., Picco, V., Raybaud, H., Sudaka, A., Chamorey, E., Brolih, S., Monteverde, M., Merlano, M., Lo Nigro, C., Ambrosetti, D., & Pagès, G. (2016). Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma. Oncotarget7(28), 44236–44251.
  • Brand, A., Singer, K., Koehl, G. E., Kolitzus, M., Schoenhammer, G., Thiel, A., et al. (2016). LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells. Cell metabolism24(5), 657-671.
  • Casado-Amezúa, P., Terrón-Sigler, A., Pinzón, J.H., Furla, P., Forcioli, D., Allemand, D., Ribes, M., and Coma, R. (2016). General Ecological Aspects of Anthozoan-Symbiodinium Interactions in the Mediterranean Sea. In The Cnidaria, Past, Present and Future: The world of Medusa and her sisters, S. Goffredo and Z. Dubinsky, eds. (Cham: Springer International Publishing), pp. 375-386.
  • Cormerais, Y., Giuliano, S., & LeFloch, R. Front B, Durivault J, Tambutte E, Massard PA, de la Ballina LR, Endou H, Wempe MF et al (2016) Genetic disruption of the multifunctional CD98/LAT1 complex demonstrates the key role of essential amino acid transport in the control of mTORC1 and tumor growth. Cancer Res76, 4481-4492.
  • Counillon, L., Bouret, Y., Marchiq, I., & Pouysségur, J. (2016). Na(+)/H(+) antiporter (NHE1) and lactate/H(+) symporters (MCTs) in pH homeostasis and cancer metabolism. Biochimica et biophysica acta1863(10), 2465–2480.
  • Halligan, D. N., Murphy, S. J., & Taylor, C. T. (2016, October). The hypoxia-inducible factor (HIF) couples immunity with metabolism. In Seminars in immunology (Vol. 28, No. 5, pp. 469-477). Academic Press.
  • Hitti, E., Bakheet, T., Al-Souhibani, N., Moghrabi, W., Al-Yahya, S., Al-Ghamdi, M., et al. (2016). Systematic analysis of AU-rich element expression in cancer reveals common functional clusters regulated by key RNA-binding proteins. Cancer research76(14), 4068-4080.
  • Marchiq, I., Pouysségur, J. (2016). Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters. J Mol Med 94, 155–171.
  • Parks, S. K., Cormerais, Y., Marchiq, I., & Pouyssegur, J. (2016). Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export. Molecular aspects of medicine47, 3-14.
  • Picco, V., Coste, I., Giraud-Panis, M.-J., Renno, T., Gilson, E., and Pagès, G. (2016). ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2. Oncotarget 7 : 46615-46627.
  • Pouysségur, J., & Lenormand, P. (2016). ERK1 and ERK2 map kinases: specific roles or functional redundancy?. Frontiers in cell and developmental biology4, 53.
  • Pouyssegur, J., & López-Barneo, J. (2016). Hypoxia in health and disease. Molecular aspects of medicine47-48, 1–2.
  • Taylor, C. T., Doherty, G., Fallon, P. G., & Cummins, E. P. (2016). Hypoxia-dependent regulation of inflammatory pathways in immune cells. The Journal of clinical investigation126(10), 3716-3724.
  • Zakraoui, O., Marcinkiewicz, C., Aloui, Z., Othman, H., Grépin, R., Haoues, M., et al. (2017). Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor‐induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression. Molecular carcinogenesis56(1), 18-35.
  • Beaugrand G., Edwards M., Raybaud V., et al. (2015). Future vulnerability of marine biodiversity compared with contemporary and past changes. Nature Climate Change 5, 695-701
  • Brahimi-Horn, M. C., Giuliano, S., Saland, E., Lacas-Gervais, S., Sheiko, T., Pelletier, J., Bourget, I., Bost, F., Féral, C., Boulter, E., Tauc, M., Ivan, M., Garmy-Susini, B., Popa, A., Mari, B., Sarry, J. E., Craigen, W. J., Pouysségur, J., & Mazure, N. M. (2015). Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation. Cancer & metabolism3, 8.
  • Brahimi-Horn, M. C., Lacas-Gervais, S., Adaixo, R., Ilc, K., Rouleau, M., Notte, A., Dieu, M., Michiels, C., Voeltzel, T., Maguer-Satta, V., Pelletier, J., Ilie, M., Hofman, P., Manoury, B., Schmidt, A., Hiller, S., Pouysségur, J., & Mazure, N. M. (2015). Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Molecular and cellular biology35(9), 1491–1505.
  • Buscà, R., Christen, R., Lovern, M., Clifford, A. M., Yue, J. X., Goss, G. G., Pouysségur, J., & Lenormand, P. (2015). ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1. BMC evolutionary biology15, 179.
  • Compan, V., Pierredon, S., Vanderperre, B., Krznar, P., Marchiq, I., Zamboni, N., Pouyssegur, J., & Martinou, J. C. (2015). Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect. Molecular cell59(3), 491–501.
  • Granja, S., Marchiq, I., Le Floch, R., Moura, C. S., Baltazar, F., & Pouysségur, J. (2015). Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status. Oncotarget6(9), 6708–6721.
  • Giuliano, S., Cormerais, Y., Dufies, M., Grépin, R., Colosetti, P., Belaid, A., Parola, J., Martin, A., Lacas-Gervais, S., Mazure, N. M., Benhida, R., Auberger, P., Mograbi, B., & Pagès, G. (2015). Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux. Autophagy11(10), 1891–1904.
  • Marchiq, I., Albrengues, J., Granja, S., Gaggioli, C., Pouysségur, J., & Simon, M. P. (2015). Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction. Oncotarget6(28), 24636–24648.
  • Marchiq, I., Le Floch, R., Roux, D., Simon, M. P., & Pouyssegur, J. (2015). Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin. Cancer research75(1), 171–180.
  • Parks, S. K., & Pouyssegur, J. (2015). The Na(+)/HCO3(-) Co-Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells. Journal of cellular physiology230(8), 1954–1963.
  • Pelletier, J., Roux, D., Viollet, B., Mazure, N. M., & Pouysségur, J. (2015). AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts. Oncotarget6(14), 11833–11847.
  • Pettersen, E. O., Ebbesen, P., Gieling, R. G., Williams, K. J., Dubois, L., Lambin, P., Ward, C., Meehan, J., Kunkler, I. H., Langdon, S. P., Ree, A. H., Flatmark, K., Lyng, H., Calzada, M. J., Peso, L. D., Landazuri, M. O., Görlach, A., Flamm, H., Kieninger, J., Urban, G., … Cojocari, D. (2015). Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium. Journal of enzyme inhibition and medicinal chemistry30(5), 689–721.
  • Pontier-Bres, R., Rampal, P., Peyron, J.F., Munro, P., Lemichez, E., and Czerucka, D. (2015). The Saccharomyces boulardii CNCM I-745 Strain Shows Protective Effects against the B. anthracis LT Toxin. Toxins 7, 4455-4467.
  • Yufune, S., Satoh, Y., Takamatsu, I., Ohta, H., Kobayashi, Y., Takaenoki, Y., Pagès, G., Pouysségur, J., Endo, S., & Kazama, T. (2015). Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice. Scientific reports5, 10252.
  • Doyen, J., Trastour, C., Ettore, F., Peyrottes, I., Toussant, N., Gal, J., Ilc, K., Roux, D., Parks, S. K., Ferrero, J. M., & Pouysségur, J. (2014). Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome. Biochemical and biophysical research communications451(1), 54–61.
  • Giuliano, S., Guyot, M., Grépin, R., & Pagès, G. (2014). The ELR+CXCL chemokines and their receptors CXCR1/CXCR2: A signaling axis and new target for the treatment of renal cell carcinoma. Oncoimmunology3, e28399.
  • Grépin, R., Ambrosetti, D., Marsaud, A., Gastaud, L., Amiel, J., Pedeutour, F., & Pagès, G. (2014). The relevance of testing the efficacy of anti-angiogenesis treatments on cells derived from primary tumors: a new method for the personalized treatment of renal cell carcinoma. PloS one9(3), e89449.
  • Grépin, R., Guyot, M., Giuliano, S., Boncompagni, M., Ambrosetti, D., Chamorey, E., et al. (2014). The CXCL7/CXCR1/2 axis is a key driver in the growth of clear cell renal cell carcinoma. Cancer research74(3), 873-883.
  • Grépin, R., Guyot, M., & Pagès, G. (2014). Resistance to Antiangiogenic Treatments via Upregulation of Substitution Pathways. Molecular Mechanisms of Angiogenesis, 397-419.
  • HoWangYin, K. Y., Loinard, C., Bakker, W., Guérin, C. L., Vilar, J., d'Audigier, C., Mauge, L., Bruneval, P., Emmerich, J., Lévy, B. I., Pouysségur, J., Smadja, D. M., & Silvestre, J. S. (2014). HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cell-based therapies for the treatment of critical limb ischemia. Stem cells (Dayton, Ohio)32(1), 231–243.
  • Hilmi N., Allemand D., Cinar M., Cooley S., Hall-Spencer J. M., Haraldsson G., Hattam C., Jeffree R. A., Orr J. C., Rehdanz K., Reynaud S., Safa A., Dupont S., 2014. 
  • Pontier-Bres R., Munro P., Boyer L., Anty R., Imbert V., Terciolo C., André F., Rampal P., Lemichez E., Peyron J-F, Czerucka D. Saccharomyces boulardii modifies Salmonella typhimurium traffic and host immune responses along the intestinal tract. PLoS One. 2014  13;9(8):e103069. doi: 10.1371
  • Simonnet, H., Vigneron, A., & Pouysségur, J. (2014). Conventional techniques to monitor mitochondrial oxygen consumption. Methods in enzymology542, 151–161.
  • Chiche, J., Ricci, J. E., & Pouysségur, J. (2013). Tumor hypoxia and metabolism -- towards novel anticancer approaches. Annales d'endocrinologie74(2), 111–114.
  • Doyen, J., Parks, S. K., Marcié, S., Pouysségur, J., & Chiche, J. (2013). Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis. Frontiers in oncology2, 199.
  • Lutz, N. W., Le Fur, Y., Chiche, J., Pouysségur, J., & Cozzone, P. J. (2013). Quantitative in vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis. Cancer research73(15), 4616–4628.
  • Parks, S., Chiche, J. & Pouysségur, J. (2013). Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer 13, 611–623.
  • Parks, S. K., Mazure, N. M., Counillon, L., & Pouysségur, J. (2013). Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels. Journal of cellular physiology228(9), 1854–1862.
  • Picco, V., & Pagès, G. (2013). Linking JNK Activity to the DNA Damage Response. Genes & cancer4(9-10), 360–368.
  • Hilmi N., Allemand D., et al., (2013). Towards improved socio-economic assessments of ocean acidification's impacts. Marine Biology 160, 1773-1787
  • Debreuil, J., Tambutte, E., Zoccola, D., Deleury, E., Guigonis, J.M., Samson, M., Allemand, D., and Tambutte, S. (2012). Molecular cloning and characterization of first organic matrix protein from Sclerites of Red Coral, Corallium rubrum. J. Biol. Chem. 287, 19367-19376.
  • Forcioli, D., Merle, P.L., Caligara, C., Ciosi, M., Muti, C., Francour, P., Cerrano, C., and Allemand, D. (2011). Symbiont diversity is not involved in depth acclimation in the Mediterranean sea whip Eunicella singularis. Mar. Ecol. Prog. Ser. 439, 57-71.
  • Furla, P., Richier, S., and Allemand, D. (2011). Physiological adaptation to symbiosis in cnidarians. In Coral reefs: An ecosystem in transition, Volume 3, Z. Dubinsky and N. Stambler, eds. (Springer Netherlands), pp. 187-195.
  • Ganot, P., Moya, A., Magnone, V., Allemand, D., Furla, P., and Sabourault, C. (2011). Adaptations to endosymbiosis in a cnidarian-dinoflagellate association: Differential gene expression and specific gene duplications. PLos Genet. 7, e1002187.
  • Pey, A., Zamoum, T., Allemand, D., Furla, P., and Merle, P.-L. (2011). Depth-dependant thermotolerance of the symbiotic Mediterranean gorgonian Eunicella singularis: Evidence from cellular stress markers. J. Exp. Mar. Biol. Ecol. 404, 73-78.
  • Richier, R., Sabourault, C., Ferrier-Pagès, C., Merle, P., Furla, P., and Allemand, D. (2010). Cnidarian / Dinoflagellate symbiosis-mediated adaptation to environmental perturbations. In Symbioses and Stress, Volume 17. (Springer), pp. 149-175.
  • Ferrier-Pages, C., Tambutté, E., Zamoum, T., Segonds, N., Merle, P.L., Bensoussan, N., Allemand, D., Garrabou, J., and Tambutté, S. (2009). Physiological response of the symbiotic gorgonian Eunicella singularis to a long-term temperature increase. J. Exp. Biol. 212, 3007-3015.
  • Sabourault, C., Ganot, P., Deleury, E., Allemand, D., and Furla, P. (2009). Comprehensive EST analysis of the symbiotic sea anemone, Anemonia viridis. BMC genomics 10, 333.
  • Zoccola, D., Moya, A., Beranger, G.E., Tambutté, E., Allemand, D., Carle, G.F., and Tambutté, S. (2009). Specific expression of BMP2/4 ortholog in biomineralizing tissues of corals and action on mouse BMP receptor. Mar. Biotechnol. 11, 260-269.
  • Allemand, D., Mayer-Gostan, N., De Pontual, H., Boeuf, G., and Payan, P. (2008). Fish otolith calcification in relation to endolymph chemistry. In Handbook of Biomineralization, Volume 1, E. Bäuerlein, ed. (Wiley-VCH Verlag GmbH), pp. 291-308.
  • Moya, A., Ferrier-Pages, C., Furla, P., Richier, S., Tambutté, E., Allemand, D., and Tambutté, S. (2008). Calcification and associated physiological parameters during a stress event in the scleractinian coral Stylophora pistillata. Comp. Biochem. Physiol. A, Mol. Integr. Physiol. 151, 29-36.
  • Moya, A., Tambutté, S., Bertucci, A., Tambutté, E., Lotto, S., Vullo, D., Supuran, C.T., Allemand, D., and Zoccola, D. (2008). Carbonic anhydrase in the scleractinian coral Stylophora pistillata - Characterization, localization, and role in biomineralization. J. Biol. Chem. 283, 25475-25484.
  • Richier, S., Cottalorda, J.-M., Guillaume, M.M.M., Fernandez, C., Allemand, D., and Furla, P. (2008). Depth-dependant response to light of the reef building coral, Pocillopora verrucosa: Implication of oxidative stress. J. Exp. Mar. Biol. Ecol. 357, 48 - 56.
  • Giunti, C., Priouzeau, F., Allemand, D., and Levraut, J. (2007). Effect of Tris-Hydroxymethyl Aminomethane on intracellular pH depends on the extracellular non-bicarbonate buffering capacity. Transl. Res. 150, 350-356.
  • Merle, P.L., Sabourault, C., Richier, S., Allemand, D., and Furla, P. (2007). Catalase characterization and implication in bleaching of a symbiotic sea anemone. Free Radic. Biol. Med. 42, 236-246.
  • Guibbolini, M., Borelli, G., Mayer-Gostan, N., Priouzeau, F., De Pontual, H., Allemand, D., and Payan, P. (2006). Characterization and variations of organic parameters in teleost fish endolymph during day-night cycle, starvation and stress conditions. Comp. Biochem. Physiol. A, Mol. Integr. Physiol. 145, 99-107.
  • Richier, S., Sabourault, C., Courtiade, J., Zucchini, N., Allemand, D. & P. Furla. (2006). Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis. FEBS Journal 273 : 4186 – 4198.
  • Muscatine, L., Goiran, C., Land, L., Jaubert, J., Cuif, J.P., and Allemand, D. (2005). Stable isotopes (δ13C and δ15N) of organic matrix from coral skeleton. PNAS 102, 1525-1530.
  • Richier, S., Furla, P., Plantivaux, A., Merle, P. L. & Allemand, D. (2005). Symbiosis-induced adaptation to oxidative stress. J Exp Biol 208 : 277-285.
  • Caligara, C., Forcioli, D., Merle, P.L., Francour, P., and Allemand, D. (2004). Etude de la diversité génétique et phénotypique chez la gorgone symbiotique méditerranéenne Eunicella singularis (Esper, 1791). Rapp. Comm. int. Mer Médit. 37, 499.
  • Plantivaux, A., Furla, P., Zoccola, D., Garello, G., Forcioli, D., Richier, S., Merle, P.-L., Tambutté, E., Tambutté, S., and Allemand, D. (2004). Molecular characterization of two CuZn-superoxide dismutases in a sea anemone. Free Radic. Biol. Med. 37, 1170-1181.
  • Allemand, D., Furla, P., Merle, P.-L., Plantaviaux, A.Richier, S., and Tambutté, S. (2003). Adaptation à la vie en symbiose des cnidaires à zooxanthelles. In Océanis. (Paris, FRANCE: Institut océanographique), p. 30.
  • Borelli, G., Guibbolini, M.E., Mayer-Gostan, N., Priouzeau, F., De Pontual, H., Allemand, D., Puverel, S., Tambutte, E., and Payan, P. (2003). Daily variations of endolymph composition: Relationship with the otolith calcification process in trout. J. Exp. Biol. 206, 2685-2692.
  • Richier, S., Merle, P.-L., Furla, P., Pigozzi, D., Sola, F., and Allemand, D. (2003). Characterization of superoxide dismutases in anoxia- and hyperoxia-tolerant symbiotic cnidarians. Biochim. Biophys. Acta 1621, 84-91.
  • Zoccola, D., Tambutte, E., Senegas-Balas, F., Michiels, J.F., Failla, J.P., Jaubert, J., and Allemand, D. (1999). Cloning of a calcium channel a1 subunit from the reef-building coral, Stylophora pistillata. Gene 227, 157-167.
  • Ferrier-Pagès, C., Allemand, D., Gattuso, J.-P., Jaubert, J., and Rassoulzadegan, F. (1998). Microheterotrophy in the zooxanthellate coral Stylophora pistillata: efects of light and ciliate density. Limnol. Oceanogr. 43, 1639-1648.
  • Ferrier-Pagès, C., Gattuso, J.-P., Cauwet, G., Jaubert, J., and Allemand, D. (1998). Release of dissolved organic carbon and nitrogen by the zooxanthellate coral Galaxea fascicularis. Mar. Ecol. Prog. Ser. 172, 265-274.
  • Furla, P., Bénazet-Tambutté, S., Jaubert, J., and Allemand, D. (1998). Diffusional permeability of dissolved inorganic carbon through the isolated oral epithelial layers of the sea anemone, Anemonia viridis. J. Exp. Mar. Biol. Ecol. 221, 71-88.
  • Furla, P., Bénazet-Tambutté, S., Jaubert, J., and Allemand, D. (1998). Functional polarity of the tentacle of the sea anemone Anemonia viridis: role in inorganic carbon acquisition. Am. Physiol. Soc. 274, R303-R310.
  • Allemand, D., De Renzis, G., and Payan, P. (1993). Effects of HgCl2 on intracellular pH in sea urchin eggs: activation of H+ excretion and Na+/H+ exchange activity. Aquat. Toxicol. 26, 171-184.
  • Karez, C.S., Allemand, D., De Renzis, G., Gnassia-Barelli, M., Romeo, M., and Puiseux-Dao, S. (1990). Ca-Cd interaction in the prymnesiophyte Cricosphaera elongata. Plant Cell Environ. 13, 483-487.
  • Romeo, M., Karez, C.S., Allemand, D., Renzis, G., Gnassia-Barelli, M., and Puiseux-Dao, S. (1990). A Study of Cadmium and Calcium Transport into a Marine Unicellular Alga. In Water and Ions in Biomolecular Systems, D. Vasilescu, J. Jaz, L. Packer and B. Pullman, eds. (Birkhäuser Basel), pp. 249-256.
  • Allemand, D., Walter, P., Delmas, P., and De Renzis, G. (1989). Alteration of calcium transport as a mechanism of cell injury induced by HgCl2 in sea urchin eggs. Mar. Environ. Res. 28, 227-230.
  • Ciapa, B., Allemand, D., and Payan, P. (1989). Effect of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TTPA) upon membrane ionic exchanges in sea urchin eggs. Exp. Cell Res. 185, 407-418.
  • Walter, P., Allemand, D., de Renzis, G., and Payan, P. (1989). Mediating effect of calcium in HgCl2 cytotoxicity in sea urchin egg: role of mitochondria in Ca2+-mediated cell death. Biochim. Biophys. Acta 1012, 219-226.
  • Allemand, D., De Renzis, G., Payan, P., Girard, J.-P., and Vaissiere, R. (1988). HgCl2-induced cell injury. Differential effects on membrane-located transport systems in unfertilized and fertilized sea urchin eggs. Toxicology 50, 217-230.