VIRULENCE OF MARINE BACTERIA
Identification and study of the expression of virulence factors of pathogenic bacteria in the marine environment for humans: a bio-informatic approach.
It is known that temperature plays a key role in the organism's metabolism and behavior, and marine bacteria are no different. The human body temperature can affect pathogenic bacteria in their virulent assets since it influences their adhesion, proliferation, and survival aspects. Nevertheless, there are scarce data that deals with the impacts of temperature change on the virulence of organisms that lives in marine environments and how they can later affect humans.
Taking this into account and the fact that climate change is an urgent matter in our society, this study aims to:
1 - Identify these marine bacteria using metagenomic approaches.
2 - Understand how these organisms can react to different scenarios of sea-water temperature increase on the expression of their virulence, evaluating their RNA expression.
DNA will be isolated from the clones of interest for genomic analysis and RNA for transcriptomic analysis. The data thus obtained, will then be analyzed by a bioinformatics approach. The samples of marine bacteria will be collected in the Mediterranean sea.
This project is a collaboration between the Institute for Research on Cancer and Aging of Nice (IRCAN) of the Côte d'Azur University (UCA) and the Scientific Center of Monaco (CSM).
The teams involved in the "Virulence of Marine Bacteria" project:
Biology Sector:
CSM: Dorota Czerucka, Rodolphe Pontier-Bres, and team.
Biotechnology Sector:
IRCAN: Olivier Croce, son stagiaire Pierre Marchal, and team.
Clinical Sector:
Centre Hospitalier Universitaire de Nice (CHU-UCA); C3M: Raymond Ruimy.
IRCAN: Mélanie Mousse
It is known that temperature plays a key role in the organism's metabolism and behavior, and marine bacteria are no different. The human body temperature can affect pathogenic bacteria in their virulent assets since it influences their adhesion, proliferation, and survival aspects. Nevertheless, there are scarce data that deals with the impacts of temperature change on the virulence of organisms that lives in marine environments and how they can later affect humans.
Taking this into account and the fact that climate change is an urgent matter in our society, this study aims to:
1 - Identify these marine bacteria using metagenomic approaches.
2 - Understand how these organisms can react to different scenarios of sea-water temperature increase on the expression of their virulence, evaluating their RNA expression.
DNA will be isolated from the clones of interest for genomic analysis and RNA for transcriptomic analysis. The data thus obtained, will then be analyzed by a bioinformatics approach. The samples of marine bacteria will be collected in the Mediterranean sea.
This project is a collaboration between the Institute for Research on Cancer and Aging of Nice (IRCAN) of the Côte d'Azur University (UCA) and the Scientific Center of Monaco (CSM).
The teams involved in the "Virulence of Marine Bacteria" project:
Biology Sector:
CSM: Dorota Czerucka, Rodolphe Pontier-Bres, and team.
Biotechnology Sector:
IRCAN: Olivier Croce, son stagiaire Pierre Marchal, and team.
Clinical Sector:
Centre Hospitalier Universitaire de Nice (CHU-UCA); C3M: Raymond Ruimy.
IRCAN: Mélanie Mousse